Abstract
The Arp2/3 complex, a 220 kDa macromolecular assembly comprising two actin-related proteins and five other subunits, plays a key role in cellular motility by initiating the polymerization of new actin filaments. Crystal and cryo-electron microscopic structures of the Arp2/3 complex and branch junctions have clarified extensive biochemical data on the mechanism of this process.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Actin-Related Protein 2
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Actin-Related Protein 3
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Actins / metabolism*
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Animals
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Cytoskeletal Proteins / chemistry*
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Cytoskeletal Proteins / metabolism*
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Macromolecular Substances
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Models, Molecular
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Protein Structure, Tertiary
Substances
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Actin-Related Protein 2
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Actin-Related Protein 3
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Actins
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Cytoskeletal Proteins
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Macromolecular Substances