Abstract
Chemical genetics, or the specific modulation of cellular systems by small molecules, has complemented classical genetic analysis throughout the history of neurobiology. We outline several of its contributions to the understanding of ion channel biology, heat and cold signal transduction, sleep and diurnal rhythm regulation, effects of immunophilin ligands, and cell surface oligosaccharides with respect to neurobiology.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Circadian Rhythm / physiology
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Humans
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Immunophilins
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Ion Channels / physiology
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Membrane Proteins / drug effects
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Membrane Proteins / metabolism
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Molecular Biology / methods*
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Molecular Biology / trends
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Molecular Probe Techniques / trends*
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Neurobiology / methods*
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Neurobiology / trends
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Thermosensing / physiology
Substances
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Ion Channels
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Membrane Proteins
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Immunophilins