Abstract
Rod signals reach ganglion cells via at least five pathways. A new study in this issue of Neuron shows that all pathways from rods to ON-type ganglion cells require connexin36. This is the first physiological demonstration in mammals that a well-defined neural circuit requires a gap junction as an obligatory transmission step.
MeSH terms
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Animals
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Connexins / metabolism*
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Dark Adaptation / physiology*
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Eye Proteins / metabolism*
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Gap Junction delta-2 Protein
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Gap Junctions / metabolism*
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Gap Junctions / ultrastructure
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Humans
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Neural Pathways / cytology
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Neural Pathways / metabolism*
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Retina / cytology
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Retina / metabolism*
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Synapses / metabolism*
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Synapses / ultrastructure
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Synaptic Transmission / physiology
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Vision, Ocular / physiology*