Inhibitors of NF-kappaB signaling: design and synthesis of a biotinylated isopanepoxydone affinity reagent

Bioorg Med Chem Lett. 2002 Dec 2;12(23):3463-6. doi: 10.1016/s0960-894x(02)00769-2.

Abstract

A number of inhibitors of NF-kappaB signaling arising from our recent syntheses of isopanepoxydone and panepoxydone have been identified. Structure-activity data have been correlated to allow the design and synthesis of an affinity reagent for the isolation and identification of any relevant cellular target.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Biotin / analogs & derivatives*
  • Biotinylation
  • Bridged Bicyclo Compounds, Heterocyclic / chemistry*
  • Bridged Bicyclo Compounds, Heterocyclic / pharmacology*
  • Cell Line
  • Drug Design
  • Electrophoresis, Polyacrylamide Gel
  • HeLa Cells
  • Humans
  • Indicators and Reagents / chemical synthesis*
  • Indicators and Reagents / pharmacology*
  • NF-kappa B / antagonists & inhibitors*
  • NF-kappa B / physiology
  • Signal Transduction / drug effects
  • Signal Transduction / physiology
  • Structure-Activity Relationship

Substances

  • Bridged Bicyclo Compounds, Heterocyclic
  • Indicators and Reagents
  • NF-kappa B
  • panepoxydone
  • Biotin