Abstract
A number of inhibitors of NF-kappaB signaling arising from our recent syntheses of isopanepoxydone and panepoxydone have been identified. Structure-activity data have been correlated to allow the design and synthesis of an affinity reagent for the isolation and identification of any relevant cellular target.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Biotin / analogs & derivatives*
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Biotinylation
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Bridged Bicyclo Compounds, Heterocyclic / chemistry*
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Bridged Bicyclo Compounds, Heterocyclic / pharmacology*
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Cell Line
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Drug Design
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Electrophoresis, Polyacrylamide Gel
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HeLa Cells
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Humans
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Indicators and Reagents / chemical synthesis*
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Indicators and Reagents / pharmacology*
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NF-kappa B / antagonists & inhibitors*
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NF-kappa B / physiology
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Signal Transduction / drug effects
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Signal Transduction / physiology
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Structure-Activity Relationship
Substances
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Bridged Bicyclo Compounds, Heterocyclic
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Indicators and Reagents
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NF-kappa B
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panepoxydone
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Biotin