Modulation of axonal regeneration in neurodegenerative disease: focus on Nogo

J Mol Neurosci. 2002 Aug-Oct;19(1-2):117-21. doi: 10.1007/s12031-002-0021-7.

Abstract

Recent work has demonstrated that axonal regeneration in the central nervous system is limited by myelin-derived Nogo binding to an axonal Nogo Receptor. The Nogo system appears to have a physiologic role in regulating structural plasticity. The possibility that the Nogo system contributes to pathologic and compensatory plasticity in Alzheimer's Disease is considered.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Alzheimer Disease / metabolism
  • Alzheimer Disease / pathology
  • Animals
  • Axons / metabolism
  • Axons / pathology*
  • GPI-Linked Proteins
  • Growth Inhibitors / metabolism*
  • Myelin Proteins / metabolism*
  • Myelin Sheath / pathology
  • Nerve Regeneration*
  • Neurodegenerative Diseases / metabolism*
  • Neurodegenerative Diseases / pathology*
  • Neuronal Plasticity
  • Nogo Proteins
  • Nogo Receptor 1
  • Receptors, Cell Surface / metabolism

Substances

  • GPI-Linked Proteins
  • Growth Inhibitors
  • Myelin Proteins
  • Nogo Proteins
  • Nogo Receptor 1
  • Receptors, Cell Surface
  • Rtn4 protein, mouse
  • Rtn4r protein, mouse