The road less traveled: transport of Legionella to the endoplasmic reticulum

Craig R Roy; Lewis G Tilney

doi:10.1083/jcb.200205011

The road less traveled: transport of Legionella to the endoplasmic reticulum

J Cell Biol. 2002 Aug 5;158(3):415-9. doi: 10.1083/jcb.200205011. Epub 2002 Jul 29.

Authors

Craig R Roy¹, Lewis G Tilney

Affiliation

¹ Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, CT 06536, USA. craig.roy@yale.edu

Abstract

Phagosomes containing the bacterial pathogen Legionella pneumophila are transported to the ER after macrophage internalization. To modulate phagosome transport, Legionella use a specialized secretion system that injects bacterial proteins into eukaryotic cells. This review will focus on recent studies that have identified bacterial proteins and host processes that play a concerted role in transporting Legionella to the ER.

Publication types

Review

MeSH terms

Animals
Bacterial Proteins / immunology
Bacterial Proteins / metabolism*
Endoplasmic Reticulum, Rough / metabolism
Endoplasmic Reticulum, Rough / microbiology*
Endoplasmic Reticulum, Rough / ultrastructure
Humans
Legionella pneumophila / immunology
Legionella pneumophila / metabolism*
Legionella pneumophila / ultrastructure
Legionnaires' Disease / metabolism*
Legionnaires' Disease / pathology
Legionnaires' Disease / physiopathology
Macrophages / metabolism
Macrophages / microbiology*
Macrophages / ultrastructure
Phagocytosis / immunology
Phagosomes / metabolism
Phagosomes / microbiology*
Phagosomes / ultrastructure
Protein Transport / immunology*
Vacuoles / metabolism
Vacuoles / microbiology
Vacuoles / ultrastructure

Substances

Bacterial Proteins