The involvement of RNA in ribosome function

Peter B Moore; Thomas A Steitz

doi:10.1038/418229a

The involvement of RNA in ribosome function

Nature. 2002 Jul 11;418(6894):229-35. doi: 10.1038/418229a.

Authors

Peter B Moore¹, Thomas A Steitz

Affiliation

¹ Department of Molecular Biophysics and Biochemistry, Yale University, PO Box 208107, New Haven, Connecticut 06520-8107, USA. peter.moore@yale.edu

PMID: 12110899
DOI: 10.1038/418229a

Abstract

The ribosome is a particle made of RNA and protein that is found in abundance in all cells that are actively making protein. It catalyses the messenger RNA-directed synthesis of proteins. Recent structural work has demonstrated a profound involvement of the ribosome's RNA component in all aspects of its function, supporting the hypothesis that proteins were added to the ribosome late in its evolution.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Binding Sites
Evolution, Molecular
Models, Chemical
Models, Molecular
RNA, Ribosomal / chemistry
RNA, Ribosomal / genetics
RNA, Ribosomal / metabolism*
RNA, Transfer / chemistry
RNA, Transfer / genetics
RNA, Transfer / metabolism
Ribosomes / chemistry
Ribosomes / genetics*
Ribosomes / metabolism*

Substances

RNA, Ribosomal
RNA, Transfer