Endothelial activation: intracellular signaling pathways

Arthritis Res. 2002;4 Suppl 3(Suppl 3):S109-16. doi: 10.1186/ar576. Epub 2002 May 9.

Abstract

Tumor necrosis factor (TNF) is the prototypic proinflammatory cytokine and endothelial cells are the principal cellular targets of its actions. Here I review the responses of endothelial cells to TNF, with emphasis on the induction of endothelial leukocyte adhesion molecules. I focus on the biochemistry and cell biology of signal transduction in TNF-treated endothelial cells that lead to the expression of adhesion molecules.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Endothelium / cytology*
  • Endothelium / immunology*
  • Humans
  • Inflammation / immunology*
  • Leukocytes / cytology
  • Leukocytes / immunology
  • Signal Transduction / immunology*