Abstract
Pamidronate is used frequently to treat malignancy-associated hypercalcemia and osteolytic lesions. This widely used bisphosphonate has been noted to cause nephrotoxicity in patients with multiple myeloma and metastatic breast cancer. We encountered a patient with Langerhans's histiocytosis who developed nephrotic syndrome and renal failure after pamidronate therapy. We describe the clinical and renal biopsy findings in this patient.
Copyright 2002 by the National Kidney Foundation, Inc.
MeSH terms
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Anti-Inflammatory Agents / adverse effects
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Anti-Inflammatory Agents / therapeutic use
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Diphosphonates / adverse effects*
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Diphosphonates / therapeutic use*
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Female
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Histiocytosis, Langerhans-Cell / drug therapy*
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Histiocytosis, Langerhans-Cell / pathology
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Humans
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Kidney Tubules / drug effects*
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Kidney Tubules / pathology
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Kidney Tubules / ultrastructure
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Microscopy, Electron
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Middle Aged
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Nephrotic Syndrome / chemically induced
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Nephrotic Syndrome / pathology
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Pamidronate
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Renal Insufficiency / chemically induced
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Renal Insufficiency / pathology
Substances
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Anti-Inflammatory Agents
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Diphosphonates
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Pamidronate