Plasma catecholamine metabolites in antidepressant-exacerbated mania and psychosis

Frank Fortunati; Carolyn Mazure; Adrian Preda; Rebecca Wahl; Malcolm Bowers Jr

doi:10.1016/s0165-0327(00)00327-x

Plasma catecholamine metabolites in antidepressant-exacerbated mania and psychosis

J Affect Disord. 2002 Apr;68(2-3):331-4. doi: 10.1016/s0165-0327(00)00327-x.

Authors

Frank Fortunati¹, Carolyn Mazure, Adrian Preda, Rebecca Wahl, Malcolm Bowers Jr

Affiliation

¹ Department of Psychiatry, Yale University, USA.

PMID: 12063160
DOI: 10.1016/s0165-0327(00)00327-x

Abstract

We measured plasma free HVA and MHPG in 39 cases of psychosis or mania judged to be caused by antidepressant exacerbation of symptoms. A total of 24 of patients had been receiving selective serotonin reuptake inhibitors (SSRI's). The SSRI group showed a pattern of increased plasma HVA similar to a comparison group of patients with a psychotic/manic relapse secondary to medication non-compliance.

MeSH terms

Adult
Antidepressive Agents / adverse effects*
Antidepressive Agents / therapeutic use
Bipolar Disorder / blood
Bipolar Disorder / chemically induced*
Bipolar Disorder / diagnosis
Catecholamines / blood*
Comorbidity
Female
Homovanillic Acid / blood
Humans
Male
Middle Aged
Psychoses, Substance-Induced / blood*
Psychoses, Substance-Induced / diagnosis
Risk Factors
Selective Serotonin Reuptake Inhibitors / adverse effects*
Selective Serotonin Reuptake Inhibitors / therapeutic use

Substances

Antidepressive Agents
Catecholamines
Serotonin Uptake Inhibitors
Homovanillic Acid