New structural clues to substrate specificity in the "ubiquitin system"

Mol Cell. 2002 Mar;9(3):453-4. doi: 10.1016/s1097-2765(02)00486-0.

Abstract

A 2.5 A crystal structure of a complex between the SUMO-conjugating enzyme Ubc9 and a protein substrate has yielded fresh insight into the specificity of protein modification by SUMO and other ubiquitin-like proteins.

MeSH terms

  • Crystallography, X-Ray
  • Ligases / chemistry*
  • Ligases / metabolism
  • Macromolecular Substances
  • Models, Molecular
  • Protein Binding
  • Protein Conformation
  • Protein Structure, Tertiary*
  • Small Ubiquitin-Related Modifier Proteins / chemistry*
  • Small Ubiquitin-Related Modifier Proteins / metabolism
  • Substrate Specificity
  • Ubiquitin-Conjugating Enzymes*

Substances

  • Macromolecular Substances
  • Small Ubiquitin-Related Modifier Proteins
  • Ubiquitin-Conjugating Enzymes
  • Ligases
  • ubiquitin-conjugating enzyme UBC9