Synthesis and biological evaluation of L- and D-configurations of 2',3'-dideoxy-4'-C-methyl-3'-oxacytidine analogues

M C Liu; M Z Luo; D E Mozdziesz; T S Lin; G E Dutschman; E A Gullen; Y C Cheng; A C Sartorelli

doi:10.1016/s0960-894x(01)00441-3

Synthesis and biological evaluation of L- and D-configurations of 2',3'-dideoxy-4'-C-methyl-3'-oxacytidine analogues

Bioorg Med Chem Lett. 2001 Sep 3;11(17):2301-4. doi: 10.1016/s0960-894x(01)00441-3.

Authors

M C Liu¹, M Z Luo, D E Mozdziesz, T S Lin, G E Dutschman, E A Gullen, Y C Cheng, A C Sartorelli

Affiliation

¹ Department of Pharmacology and Developmental Therapeutics Program, Cancer Center, Yale University School of Medicine, New Haven, CT 06520-8066, USA.

PMID: 11527719
DOI: 10.1016/s0960-894x(01)00441-3

Abstract

Novel L- and D-configuration 2',3'-dideoxy-4'-C-methyl-3'-oxacytidine and their 5-fluoro analogues have been synthesized from 1-benzyloxy-2-propanone and L-ascorbic acid in eight steps and evaluated for biological activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology*
Antiviral Agents / chemical synthesis
Antiviral Agents / chemistry*
Antiviral Agents / pharmacology*
Cytidine / chemistry
Drug Screening Assays, Antitumor
Leukemia L1210
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Molecular Structure

Substances

Antineoplastic Agents
Antiviral Agents
Cytidine