Helical membrane proteins: diversity of functions in the context of simple architecture

Curr Opin Struct Biol. 2001 Jun;11(3):370-6. doi: 10.1016/s0959-440x(00)00217-7.

Abstract

During the past year, research on helical membrane proteins has brought insights into the use of deviations from canonical alpha-helical conformation to support function and the further investigation of the sequestration of protein regions from the lipid bilayer to enhance these structural alternatives. Also, the structural roles of polar sidechains, the identification of motifs in helix interactions and the significance of certain topologies on a genome-wide scale have been further explored.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Membrane Lipids / chemistry
  • Membrane Lipids / metabolism
  • Membrane Proteins / chemistry*
  • Membrane Proteins / metabolism*
  • Protein Conformation
  • Protein Folding*

Substances

  • Membrane Lipids
  • Membrane Proteins