Repulsive factors and axon regeneration in the CNS

Curr Opin Neurobiol. 2001 Feb;11(1):89-94. doi: 10.1016/s0959-4388(00)00178-1.

Abstract

During the past year, a major advance in the study of axon regeneration was the molecular cloning of Nogo. The expression of Nogo protein by CNS myelin may be a major factor in the failure of CNS axon regeneration. The effect of disrupting Nogo-dependent axon inhibition can now be studied conclusively. In related work, immunization with a Nogo-containing CNS myelin preparation was shown to promote regeneration and dramatic functional recovery after spinal cord trauma.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Axons / physiology*
  • Central Nervous System / cytology
  • Central Nervous System / physiology*
  • Humans
  • Myelin Proteins / physiology
  • Myelin Sheath / physiology
  • Nerve Growth Factors / physiology*
  • Nerve Regeneration / physiology*
  • Nogo Proteins

Substances

  • Myelin Proteins
  • Nerve Growth Factors
  • Nogo Proteins
  • RTN4 protein, human