Fibrogenesis. V. TGF-beta signaling pathways

Am J Physiol Gastrointest Liver Physiol. 2000 Nov;279(5):G845-50. doi: 10.1152/ajpgi.2000.279.5.G845.

Abstract

Transforming growth factor (TGF)-beta is a multifunctional peptide growth factor with a wide range of potential effects on growth, differentiation, extracellular matrix deposition, and the immune response. General TGF-beta signaling pathways have been described in detail over the last several years, but factors that determine the nature of the TGF-beta response are poorly understood. In particular, signaling pathways that specifically mediate the matrix effects of TGF-beta have received little attention, although they will be important therapeutic targets in the treatment of pathological fibrosis. This themes article focuses on TGF-beta signaling and highlights potential points for generating matrix-specific responses.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • Liver Cirrhosis / physiopathology*
  • Signal Transduction / physiology*
  • Transforming Growth Factor beta / physiology*

Substances

  • Transforming Growth Factor beta