Disease progression in sporadic inclusion body myositis: observations in 78 patients

Neurology. 2000 Jul 25;55(2):296-8. doi: 10.1212/wnl.55.2.296.

Abstract

Functional decline for each decade at symptom onset and need for cane, walker, or wheelchair were assessed in 78 biopsy-proved patients with sporadic inclusion body myositis. Patients with disease onset between 40 and 59 years used a walker after 10.2 +/- 5.8 years, whereas those with disease onset between 60 and 79 years used a walker after 5.7 +/- 5.0 years (p = 0.05). Because patients progress faster to disability when symptoms begin after the age of 60, age at disease onset may define patient subsets for stratification in clinical trials.

MeSH terms

  • Adult
  • Aged
  • Disability Evaluation
  • Disease Progression
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myositis, Inclusion Body / diagnosis*
  • Neurologic Examination