Hereditary inclusion-body myopathy (h-IBM) is a heterogeneous group of disorders characterized by progressive weakness of some skeletal muscles and pathological feature, intercellular rimmed vacuoles in the muscular filaments. h-IBM is not associated with inflammatory infiltrations and term myopathy is used as opposite to spontaneous inclusion-body myositis. h-IBM is classified into autosomal recessive and autosomal dominant subgroups.