Abstract
Genetic and functional characterization of the cephalosporinases produced by 65 clonally unrelated clinical Escherichia coli isolates revealed genetic diversity of the ampC genes and showed that Gln287, Cys287, Pro296, Leu298, and Phe350 substitutions were involved in extension of the hydrolysis spectrum to include ceftazidime and cefepime.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / metabolism
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / chemistry
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism*
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Cefepime
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Ceftazidime / metabolism
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Ceftazidime / pharmacology*
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Cephalosporinase / chemistry
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Cephalosporinase / genetics
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Cephalosporinase / metabolism
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Cephalosporins / metabolism
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Cephalosporins / pharmacology*
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Escherichia coli / classification
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Escherichia coli / drug effects
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Escherichia coli / enzymology*
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Escherichia coli / genetics
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Genetic Variation
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Humans
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Mutation
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Sequence Analysis, DNA
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beta-Lactam Resistance
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beta-Lactamases / chemistry
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beta-Lactamases / genetics
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beta-Lactamases / metabolism*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Cephalosporins
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Cefepime
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Ceftazidime
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Cephalosporinase
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AmpC beta-lactamases
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beta-Lactamases
Associated data
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GENBANK/AY533244
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GENBANK/AY533245
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GENBANK/DQ091197
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GENBANK/DQ091198
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GENBANK/DQ092421
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GENBANK/DQ092422
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GENBANK/DQ092423
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GENBANK/DQ092424
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GENBANK/DQ092425
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GENBANK/DQ092426
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GENBANK/DQ092427
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GENBANK/DQ092428
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GENBANK/DQ092429
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GENBANK/DQ092430
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GENBANK/DQ092431
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GENBANK/DQ092432
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GENBANK/DQ092433
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GENBANK/DQ092434