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Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease.
Science. 2016 Mar 11;351(6278):1166-71. doi: 10.1126/science.aad3517.
Science. 2016.
PMID: 26965621
Free PMC article.
Scavenger receptor BI (SR-BI) is the major receptor for high-density lipoprotein (HDL) cholesterol (HDL-C). In humans, high amounts of HDL-C in plasma are associated with a lower risk of coronary …
Scavenger receptor BI (SR-BI) is the major receptor for high-density lipoprotein (HDL) choleste …
Rare SCARB1 mutations associate with high-density lipoprotein cholesterol but not with coronary artery disease.
Helgadottir A, Sulem P, Thorgeirsson G, Gretarsdottir S, Thorleifsson G, Jensson BÖ, Arnadottir GA, Olafsson I, Eyjolfsson GI, Sigurdardottir O, Thorsteinsdottir U, Gudbjartsson DF, Holm H, Stefansson K.
Helgadottir A, et al.
Eur Heart J. 2018 Jun 14;39(23):2172-2178. doi: 10.1093/eurheartj/ehy169.
Eur Heart J. 2018.
PMID: 29596577
Free PMC article.
AIMS: Scavenger receptor Class B Type 1 (SR-BI) is a major receptor for high-density lipoprotein (HDL) that promotes hepatic uptake of cholesterol from HDL. A rare mutation p.P376L, in the gene encoding SR-BI, SCARB1, …
AIMS: Scavenger receptor Class B Type 1 (SR-BI) is a major receptor for high-density lipoprotein (HDL) th …
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