Myelodysplastic syndrome with myelofibrosis and basophilia: detection of trisomy 8 in basophils by fluorescence in-situ hybridization

Leuk Lymphoma. 1998 Oct;31(3-4):429-32. doi: 10.3109/10428199809059238.

Abstract

We report a case of myelodysplastic syndrome (MDS) with myelofibrosis and pulmonary tuberculosis who had marked basophilia in the peripheral blood. A clonal karyotypic abnormality characterized by trisomy 8 was demonstrated by cytogenetic analysis. By correlation of cell morphology with results of fluorescence in situ hybridization using a chromosome 8 probe, we demonstrated that the basophils were not reactive but belonged to the neoplastic MDS clone.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anemia, Refractory / complications
  • Anemia, Refractory / genetics*
  • Anemia, Refractory / pathology
  • Anemia, Refractory / physiopathology*
  • Basophils / pathology
  • Chromosomes, Human, Pair 8*
  • Female
  • Humans
  • In Situ Hybridization, Fluorescence
  • Primary Myelofibrosis / complications
  • Primary Myelofibrosis / genetics
  • Primary Myelofibrosis / pathology
  • Primary Myelofibrosis / physiopathology
  • Trisomy*
  • Tuberculosis, Pulmonary / complications
  • Tuberculosis, Pulmonary / genetics*
  • Tuberculosis, Pulmonary / physiopathology*