Abstract
We report a case of myelodysplastic syndrome (MDS) with myelofibrosis and pulmonary tuberculosis who had marked basophilia in the peripheral blood. A clonal karyotypic abnormality characterized by trisomy 8 was demonstrated by cytogenetic analysis. By correlation of cell morphology with results of fluorescence in situ hybridization using a chromosome 8 probe, we demonstrated that the basophils were not reactive but belonged to the neoplastic MDS clone.
MeSH terms
-
Adult
-
Anemia, Refractory / complications
-
Anemia, Refractory / genetics*
-
Anemia, Refractory / pathology
-
Anemia, Refractory / physiopathology*
-
Basophils / pathology
-
Chromosomes, Human, Pair 8*
-
Female
-
Humans
-
In Situ Hybridization, Fluorescence
-
Primary Myelofibrosis / complications
-
Primary Myelofibrosis / genetics
-
Primary Myelofibrosis / pathology
-
Primary Myelofibrosis / physiopathology
-
Trisomy*
-
Tuberculosis, Pulmonary / complications
-
Tuberculosis, Pulmonary / genetics*
-
Tuberculosis, Pulmonary / physiopathology*