Abstract
The M-current regulates the subthreshold electrical excitability of many neurons, determining their firing properties and responsiveness to synaptic input. To date, however, the genes that encode subunits of this important channel have not been identified. The biophysical properties, sensitivity to pharmacological blockade, and expression pattern of the KCNQ2 and KCNQ3 potassium channels were determined. It is concluded that both these subunits contribute to the native M-current.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Animals
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Anthracenes / pharmacology
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Brain / metabolism
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Ganglia, Sympathetic / metabolism
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Gene Expression
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Humans
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Indoles / pharmacology
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KCNQ2 Potassium Channel
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KCNQ3 Potassium Channel
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Kinetics
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Neurons / drug effects
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Neurons / physiology
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Oocytes
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Patch-Clamp Techniques
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Potassium / metabolism*
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Potassium Channels / chemistry
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Potassium Channels / drug effects
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Potassium Channels / genetics
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Potassium Channels / metabolism*
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Potassium Channels, Voltage-Gated
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Pyridines / pharmacology
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Rats
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Sympathetic Nervous System / drug effects
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Sympathetic Nervous System / physiology
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Tetraethylammonium / pharmacology
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Xenopus
Substances
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10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone
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Anthracenes
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Indoles
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KCNQ2 Potassium Channel
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KCNQ2 protein, human
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KCNQ3 Potassium Channel
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KCNQ3 protein, human
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Kcnq2 protein, rat
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Kcnq3 protein, rat
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Potassium Channels
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Potassium Channels, Voltage-Gated
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Pyridines
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Tetraethylammonium
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linopirdine
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Potassium