Functional evidence for a nasopharyngeal carcinoma tumor suppressor gene that maps at chromosome 3p21.3

Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3042-7. doi: 10.1073/pnas.95.6.3042.

Abstract

Nasopharyngeal carcinoma is a malignancy that is prevalent among populations from Southeast Asia. Epidemiological studies indicate that genetic predisposition, Epstein-Barr virus, and environmental conditions may play a role in determining incidence. Molecular studies have implicated a tumor suppressor gene(s) on the short arm of chromosome 3. In this study we provide functional evidence, via monochromosome transfer, for a tumor suppressor gene(s) activity in chromosome 3p21.3.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Carcinoma / genetics*
  • Chromosomes, Human, Pair 3*
  • Female
  • Genes, Tumor Suppressor*
  • Humans
  • Hybrid Cells
  • In Situ Hybridization, Fluorescence
  • Mice
  • Mice, Nude
  • Microsatellite Repeats
  • Nasopharyngeal Neoplasms / genetics*
  • Tumor Cells, Cultured