De novo AML with trilineage myelodysplasia and a novel t(11;12)(p15;q13)

Cancer Genet Cytogenet. 1998 Jan 1;100(1):49-51. doi: 10.1016/s0165-4608(97)00007-1.

Abstract

De novo acute myeloid leukemia with trilineage myelodysplasia (AML/TMDS) is an uncommon form of leukemia characterized by a dyshematopoietic picture accompanying the acute leukemia, a poor response to induction chemotherapy, and a tendency to relapse with pure myelodysplastic syndrome. Cytogenetic information on this entity is scarce, although some cases have been reported to be associated with t(7;11)(p15;p15). A 41-year-old woman who had a history of radiotherapy for breast cancer presented with AML/TMDS and was found to have a unique t(11;12)(p15;q13) abnormality.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Chromosomes, Human, Pair 11*
  • Chromosomes, Human, Pair 12*
  • Female
  • Humans
  • Leukemia, Myeloid, Acute / genetics*
  • Myelodysplastic Syndromes / genetics*
  • Translocation, Genetic*