The aim of the present study was to compare the peri-implant mucosal conditions 1 year after immediate transmucosal implant placement without or in combination with guided tissue regeneration with the situation after regular placement of transmucosal 1-stage procedure implants in partially edentulous patients. The test group consisted of 15 patients who required the immediate replacement of 20 teeth with oral implants in combination with guided tissue regeneration. The control group 1 consisted of 6 patients who received 8 immediate implants, without concomitant bone regeneration procedure due to the small size of the extracted roots in comparison with diameter of the implants. The 20 patients of the control group 2 were randomly chosen from over 150 partially edentulous patients who received implants of the ITI Dental Implant System according to the standard procedure. Similar favorable clinical parameters were found around the implants of all the 3 groups with low plaque and mucosal indices, similar amounts of recession, pocket probing depths and clinical attachment levels. The immediate implants demonstrated lower frequencies of sites bleeding on probing. The study has established that immediate oral implants are a feasible treatment modality with high predictability.