The effectiveness of fluoride (F) dentifrices in reducing dental caries is well documented. However, not all F dentifrices are equally effective. The objective of this study was to compare fluoride uptake from Thai, Chinese and Indian dentifrices which are widely used in these respective countries. A non-fluoride dentifrice was included as a control. Dentifrices were analysed for fluoride concentrations using the 'acid-etch biopsy technique'. This study suggests that, when compared to 'multinational dentifrices', the Thai, Chinese and Indian dentifrices manufactured locally failed to show the F availability and/or F uptake efficacy even though they claimed to contain varying levels of F.