Scavengase p20: a novel family of bacterial antioxidant enzymes

FEBS Lett. 1997 Apr 21;407(1):32-6. doi: 10.1016/s0014-5793(97)00302-5.

Abstract

A novel antioxidant enzyme designated scavengase p20 was identified in various pathogenic bacteria through database searching for sequences strikingly homologous to a recently discovered Escherichia coli thiol peroxidase p20. The direct biochemical evidence for the existence of scavengase p20 in Haemophilus influenzae, Streptococcus pneumoniae and Helicobacter pylori was provided by protein microsequencing and by in vitro assays for antioxidant activities. Overlapping genes encoding scavengase p20 and superoxide dismutase were recognized in H. pylori and their functional implications are discussed.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Antioxidants / metabolism*
  • Bacteria / enzymology*
  • Bacteria / genetics
  • Base Sequence
  • Databases, Factual
  • Escherichia coli Proteins*
  • Genes, Bacterial*
  • Haemophilus influenzae / enzymology
  • Haemophilus influenzae / genetics
  • Helicobacter pylori / enzymology
  • Helicobacter pylori / genetics
  • Molecular Sequence Data
  • Multigene Family
  • Periplasmic Proteins*
  • Peroxidases / genetics
  • Peroxidases / metabolism*
  • Sequence Homology, Amino Acid
  • Species Specificity
  • Streptococcus pneumoniae / enzymology
  • Streptococcus pneumoniae / genetics
  • Superoxide Dismutase

Substances

  • Antioxidants
  • Escherichia coli Proteins
  • Periplasmic Proteins
  • Peroxidases
  • Tpx protein, E coli
  • Superoxide Dismutase

Associated data

  • GENBANK/U93212