Hepatic events after bone marrow transplantation in patients with hepatitis B infection: a case controlled study

Bone Marrow Transplant. 1997 Apr;19(8):795-9. doi: 10.1038/sj.bmt.1700744.

Abstract

Hepatitis B reactivation following chemotherapy withdrawal may result in hepatitis, hepatic failure and death. We studied the clinical outcome and the causes of hepatic events of hepatitis B surface antigen positive recipients undergoing bone marrow transplantation. Twenty-four hepatitis B surface antigen patients were matched with 24 hepatitis B surface antigen negative patients for age, sex, CMV positive serology, underlying hematological disease and type of bone marrow transplantation. Post-BMT, there were 18 patients in the hepatitis B surface antigen positive group and four patients in the hepatitis B surface antigen negative group who suffered from hepatitis (P < 0.05). Thirteen of the 18 hepatitis were related to HBV reactivation in the hepatitis B surface antigen positive group and none of the four hepatitis in the hepatitis B surface antigen negative group (P = 0.01). The hepatitis B surface antigen positive group also had an increased incidence of acute graft-versus-host disease of liver (6 vs 1, P = 0.03). However, there was no significant increase in the incidence of veno-occlusive disease (10 vs 7, P = 0.40) and persistent hepatitis (3 vs 0, P = 0.07) in the hepatitis B surface antigen positive group. Using the log-rank test, there was no significant difference in survival between the hepatitis B surface antigen positive and negative recipients.

MeSH terms

  • Adult
  • Bone Marrow Transplantation / adverse effects*
  • Case-Control Studies
  • DNA, Viral / blood
  • Female
  • Graft vs Host Disease / etiology
  • Hepatic Veno-Occlusive Disease / etiology
  • Hepatitis B / complications*
  • Hepatitis B Surface Antigens / blood
  • Hepatitis, Chronic / etiology
  • Humans
  • Leukemia / complications*
  • Leukemia / therapy*
  • Liver Failure / etiology
  • Male
  • Recurrence

Substances

  • DNA, Viral
  • Hepatitis B Surface Antigens