Biclonal B-cell chronic lymphocytic leukemia with inv(14)(q11q32)

Cancer Genet Cytogenet. 1997 Apr;94(2):135-7. doi: 10.1016/s0165-4608(96)00222-1.

Abstract

Cytogenetic biclonality is a rare occurrence in chronic lymphocytic leukemia. A 59-year-old man was diagnosed to have B-cell chronic lymphocytic leukemia with typical morphology and immunophenotype (CD5+, CD19+, and CD23+). However, karyotypic analysis of the small lymphocytes showed the presence of two distinct unrelated clones, including one with inv(14).

MeSH terms

  • Aged
  • Chromosome Aberrations / pathology*
  • Chromosome Banding
  • Chromosome Disorders
  • Chromosome Inversion
  • Chromosomes, Human, Pair 13*
  • Chromosomes, Human, Pair 14*
  • Clone Cells
  • Humans
  • Leukemia, Lymphoid / genetics
  • Leukemia, Lymphoid / pathology*
  • Male