Expression of an abnormal sized c-kit transcript in Hong Kong Chinese acute lymphoblastic leukaemia patients

C H Chui; F Y Lau; A H Chan; J C Tang; C H Hui; C C Lam; L C Chan; G Cheng

Expression of an abnormal sized c-kit transcript in Hong Kong Chinese acute lymphoblastic leukaemia patients

Clin Lab Haematol. 1996 Dec;18(4):261-3.

Authors

C H Chui¹, F Y Lau, A H Chan, J C Tang, C H Hui, C C Lam, L C Chan, G Cheng

Affiliation

¹ Department of Pathology, Faculty of Medicine, The University of Hong Kong.

PMID: 9054699

Abstract

Blast cells from a majority of acute myelogenous leukaemia (AML) patients express c-kit mRNA. However, c-kit expression has not been observed in patients with acute lymphoblastic leukaemia (ALL) and lymphoproliferative disease. We report here the detection of an abnormal sized c-kit mRNA in two Hong Kong Chinese patients with pre-B ALL and common ALL.

Publication types

Case Reports

MeSH terms

Adult
Bone Marrow / physiology
Child
China / ethnology
DNA / analysis
Female
Gene Amplification / genetics
Gene Expression Regulation, Leukemic / genetics*
Gene Expression Regulation, Leukemic / physiology
Gene Rearrangement / genetics
Hong Kong
Humans
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / genetics
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / physiopathology
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / physiopathology
Proto-Oncogene Proteins c-kit / genetics*
RNA, Neoplasm / genetics*
RNA, Neoplasm / physiology
Transcription, Genetic

Substances

RNA, Neoplasm
DNA
Proto-Oncogene Proteins c-kit