A disc plate assay for characterization of the effect of interaction between polyenes and azoles on growth of Candida albicans CA12

B Cao; P W Tsang; D N Tsang; L P Samaranayake; J Wang

A disc plate assay for characterization of the effect of interaction between polyenes and azoles on growth of Candida albicans CA12

Microbios. 1996;87(352):161-7.

Authors

B Cao¹, P W Tsang, D N Tsang, L P Samaranayake, J Wang

Affiliation

¹ Department of Biochemistry, Faculty of Medicine, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

PMID: 9050253

Abstract

A simple, reproducible and efficient assay was described for visual demonstration that triazole fluconazole interfered with the anti-Candida albicans activity of polyene amphotericin B. The assay also indicated the existence of more than one antifungal mechanism involving imidazole ketoconazole.

MeSH terms

Amphotericin B / pharmacology*
Antifungal Agents / pharmacology*
Candida albicans / drug effects*
Candida albicans / growth & development
Drug Antagonism*
Fluconazole / pharmacology*
Ketoconazole / pharmacology*
Microbial Sensitivity Tests / methods*

Substances

Antifungal Agents
Amphotericin B
Fluconazole
Ketoconazole