Abstract
By solution-hybridization-RNase protection assay, the preproenkephalin (PPek) mRNA in the anterior pituitary (AL) of male rats was found to decrease by 42% after 3 weeks haloperidol treatment. It is concluded that dopamine may stimulate the AL enkephalinergic system at the level of gene expression.
MeSH terms
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Animals
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Dopamine Antagonists / pharmacology*
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Electrophoresis, Polyacrylamide Gel
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Enkephalins / analysis
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Enkephalins / genetics*
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Gene Expression / drug effects
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Haloperidol / pharmacology*
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Male
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Nucleic Acid Hybridization
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Pituitary Gland / chemistry
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Pituitary Gland / drug effects*
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Pituitary Gland / physiology
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Protein Precursors / analysis
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Protein Precursors / genetics*
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RNA, Messenger / analysis
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RNA, Messenger / metabolism
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Rats
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Rats, Sprague-Dawley
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Ribonucleases
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Time Factors
Substances
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Dopamine Antagonists
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Enkephalins
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Protein Precursors
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RNA, Messenger
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preproenkephalin
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Ribonucleases
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Haloperidol