Abstract
1. The physiological significance of communication through gap junction channels has been difficult to assess because channel activity cannot be experimentally modulated in a specific manner. To address this problem we have constructed chimeric connexins that function as dominant-negative inhibitors of intercellular channel activity.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cell Communication / drug effects*
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Connexins / genetics*
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Connexins / pharmacology*
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Electrophysiology
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Fibrosarcoma
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Mice
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Microinjections
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Oocytes / physiology
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Recombinant Fusion Proteins / pharmacology*
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Transfection
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Tumor Cells, Cultured
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Xenopus
Substances
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Connexins
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Recombinant Fusion Proteins