Cyclic ADP-ribose and calcium signaling in eggs

Biol Signals. 1996 Mar-Apr;5(2):101-10. doi: 10.1159/000109179.

Abstract

Cyclic ADP-ribose is a cyclic nucleotide with Ca2+ signaling functions. It was first discovered in sea urchin eggs and has since been shown to be active in a variety of cells. Another Ca2+ release mechanism recently described in the eggs is mediated by nicotinic acid dinucleotide phosphate, a derivative of NADP+. This article summarizes current results on these two novel Ca(2+)-mobilizing pathways that are independent of inositol trisphosphate.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • ADP-ribosyl Cyclase
  • ADP-ribosyl Cyclase 1
  • Adenosine Diphosphate Ribose / analogs & derivatives*
  • Adenosine Diphosphate Ribose / metabolism
  • Animals
  • Antigens, CD*
  • Antigens, Differentiation / metabolism
  • Calcium / metabolism*
  • Cyclic ADP-Ribose
  • N-Glycosyl Hydrolases / metabolism
  • NADP / analogs & derivatives*
  • NADP / metabolism
  • Ovum / physiology*
  • Sea Urchins
  • Signal Transduction*

Substances

  • Antigens, CD
  • Antigens, Differentiation
  • Cyclic ADP-Ribose
  • Adenosine Diphosphate Ribose
  • NADP
  • NAADP
  • N-Glycosyl Hydrolases
  • ADP-ribosyl Cyclase
  • ADP-ribosyl Cyclase 1
  • Calcium