Abstract
Cyclic ADP-ribose is a cyclic nucleotide with Ca2+ signaling functions. It was first discovered in sea urchin eggs and has since been shown to be active in a variety of cells. Another Ca2+ release mechanism recently described in the eggs is mediated by nicotinic acid dinucleotide phosphate, a derivative of NADP+. This article summarizes current results on these two novel Ca(2+)-mobilizing pathways that are independent of inositol trisphosphate.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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ADP-ribosyl Cyclase
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ADP-ribosyl Cyclase 1
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Adenosine Diphosphate Ribose / analogs & derivatives*
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Adenosine Diphosphate Ribose / metabolism
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Animals
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Antigens, CD*
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Antigens, Differentiation / metabolism
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Calcium / metabolism*
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Cyclic ADP-Ribose
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N-Glycosyl Hydrolases / metabolism
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NADP / analogs & derivatives*
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NADP / metabolism
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Ovum / physiology*
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Sea Urchins
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Signal Transduction*
Substances
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Antigens, CD
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Antigens, Differentiation
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Cyclic ADP-Ribose
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Adenosine Diphosphate Ribose
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NADP
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NAADP
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N-Glycosyl Hydrolases
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ADP-ribosyl Cyclase
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ADP-ribosyl Cyclase 1
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Calcium