Isolation and characterization of the first simian immunodeficiency virus from a feral sooty mangabey (Cercocebus atys) in West Africa

J Med Primatol. 1995 May;24(3):108-15. doi: 10.1111/j.1600-0684.1995.tb00155.x.

Abstract

The lineage of HIV-2-like viruses was studied in feral sooty mangabeys (SMs) by serological and genetic methods. Four feral sooty mangabeys were positive for simian immunodeficiency virus (SIV) antibodies and a new isolate, SIVsmSL92a, was obtained. Genetic analysis of gag genes showed that SIVsmSL92a was highly diverse and a distinct sequence subtype within the SIV sm/HIV-2 family. The results showed that SIVsm is the most diverse group of SIVs found thus far in a single monkey species.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Africa, Western
  • Animals
  • Base Sequence
  • Blotting, Western
  • Cercocebus atys / virology*
  • Cloning, Molecular
  • Cross Reactions
  • Gene Products, gag / chemistry
  • Gene Products, gag / genetics*
  • Leukocytes, Mononuclear / virology
  • Macaca mulatta / virology
  • Molecular Sequence Data
  • Phylogeny
  • Polymerase Chain Reaction
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Serologic Tests
  • Simian Immunodeficiency Virus / genetics*
  • Simian Immunodeficiency Virus / isolation & purification*

Substances

  • Gene Products, gag

Associated data

  • GENBANK/U17646