Chromosomal localization of the human gene encoding the 51-kDa subunit of mitochondrial complex I (NDUFV1) to 11q13

S T Ali; A M Duncan; K Schappert; H H Heng; L C Tsui; W Chow; B H Robinson

doi:10.1006/geno.1993.1493

Chromosomal localization of the human gene encoding the 51-kDa subunit of mitochondrial complex I (NDUFV1) to 11q13

Genomics. 1993 Nov;18(2):435-9. doi: 10.1006/geno.1993.1493.

Authors

S T Ali¹, A M Duncan, K Schappert, H H Heng, L C Tsui, W Chow, B H Robinson

Affiliation

¹ Department of Genetics, University of Toronto, Ontario, Canada.

PMID: 8288251
DOI: 10.1006/geno.1993.1493

Abstract

The 51-kDa flavoprotein subunit of mitochondrial NADH:ubiquinone oxidoreductase (Complex I) [NADH dehydrogenase (ubiquinone), flavoprotein 1 (51 kDa); EC 1.6.5.3] plays an important role in the formation of the NADH-binding site and is believed to be the principal site of entry for electrons donated by NADH into the respiratory chain. Human cDNA fragments of the 51-kDa protein were generated by polymerase chain reaction and used to localize the gene (NDUFV1) for this subunit to 11q13 by two separate techniques. This region of the human genome is strongly implicated in a number of different forms of cancer.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 11*
Cloning, Molecular
DNA
Electron Transport Complex I
Humans
In Situ Hybridization
Mitochondria / enzymology*
Molecular Sequence Data
NADH, NADPH Oxidoreductases / genetics*
Polymerase Chain Reaction

Substances

DNA
NADH, NADPH Oxidoreductases
Electron Transport Complex I