Prodepin: a new product of the adrenomedullin (ADM) gene has systemic vasodilator activity

H Lippton; Y Gao; B Lin; J Heaton; J Ferrara; M DeVito; T Granger; J Pigott; J K Chang; A Hyman

doi:10.1016/0024-3205(94)90124-4

Prodepin: a new product of the adrenomedullin (ADM) gene has systemic vasodilator activity

Life Sci. 1994;54(23):PL409-12. doi: 10.1016/0024-3205(94)90124-4.

Authors

H Lippton¹, Y Gao, B Lin, J Heaton, J Ferrara, M DeVito, T Granger, J Pigott, J K Chang, A Hyman

Affiliation

¹ Department of Internal Medicine, Louisiana State University Medical School, New Orleans 70112.

PMID: 8196484
DOI: 10.1016/0024-3205(94)90124-4

Abstract

The purpose of the present study was to investigate the effects of products of the ADM gene other than ADM on systemic hemodynamics in the anesthetized rat, rabbit, piglet, cat and dog. Bolus intravenous (i.v.) injections of rat proADM22-41 (3-30 micrograms) significantly decreased systemic arterial pressure (SAP) and systemic vascular resistance in the anesthetized rat. Unlike ADM, rat proADM22-41 markedly increased cardiac output in the rat. Bolus i.v. injections of human proADM22-41 up to 500 micrograms had not effect in all species studied and rat proADM22-41 had no effect in species other than the rat. The present data suggest that rat proADM22-41 is a novel product of the ADM gene other than ADM and possesses marked systemic vasodilator activity. The present data also suggest that the hemodynamic activity of this peptide is species specific.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Adrenomedullin
Animals
Cats
Dogs
Peptide Fragments / pharmacology*
Peptides / genetics
Peptides / pharmacology*
Protein Precursors / pharmacology*
Rabbits
Rats
Rats, Sprague-Dawley
Swine
Vasodilator Agents / pharmacology*

Substances

Peptide Fragments
Peptides
Protein Precursors
Vasodilator Agents
Adrenomedullin
prodepin

Grants and funding

HL11802/HL/NHLBI NIH HHS/United States