Case report: colonic stricture and fibrosis associated with high-strength pancreatic enzymes in a child with cystic fibrosis

Br J Radiol. 1994 Sep;67(801):900-1. doi: 10.1259/0007-1285-67-801-900.

Abstract

High-strength pancreatic enzymes have recently been implicated as a cause of colonic strictures in children with cystic fibrosis (CF). We report a 5-year-old boy with CF who had a stricture of the hepatic flexure region with associated narrowing due to submucosal fibrosis of the transverse colon, secondary to high-lipase pancreatin therapy.

Publication types

  • Case Reports

MeSH terms

  • Child, Preschool
  • Colon / diagnostic imaging
  • Colon / pathology*
  • Colonic Diseases / chemically induced*
  • Colonic Diseases / diagnostic imaging
  • Cystic Fibrosis / drug therapy*
  • Fibrosis
  • Follow-Up Studies
  • Humans
  • Intestinal Obstruction / chemically induced*
  • Intestinal Obstruction / diagnostic imaging
  • Male
  • Pancreatin / adverse effects*
  • Pancreatin / therapeutic use
  • Radiography

Substances

  • Pancreatin