Refractory cytopenia with t(1;7),+8 abnormality and dysplastic eosinophils showing intranuclear Charcot-Leyden crystals: a fluorescence in situ hybridization study

Br J Haematol. 1995 May;90(1):216-8. doi: 10.1111/j.1365-2141.1995.tb03405.x.

Abstract

A case of refractory cytopenia and marrow eosinophilia showing t(1;7) translocation and concomitant trisomy 8 is reported. The eosinophils were dysplastic, and showed the unique feature of intranuclear Charcot-Leyden crystal formation, giving rise to a 'lip-like' appearance. We speculate that this unusual cytologic feature resulted from abnormal precipitation of Charcot-Leyden crystal protein in the eosinophils. By fluorescence in situ hybridization using a chromosome 8 specific alpha-satellite probe, the abnormal eosinophils were shown to have derived from the abnormal clone. We postulate that the dysplastic clone might have retained a differentiation potential and be responsive to normal haemopoietic stimuli.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anemia, Refractory / genetics
  • Anemia, Refractory / pathology*
  • Bone Marrow / pathology
  • Chromosome Aberrations*
  • Chromosomes, Human, Pair 1
  • Chromosomes, Human, Pair 7
  • Chromosomes, Human, Pair 8
  • Eosinophilia / pathology*
  • Eosinophils / pathology*
  • Female
  • Glycoproteins / analysis*
  • Humans
  • In Situ Hybridization, Fluorescence
  • Lysophospholipase
  • Translocation, Genetic
  • Trisomy

Substances

  • Glycoproteins
  • Lysophospholipase
  • lysolecithin acylhydrolase