Abstract
A morbillivirus has been isolated and added to an increasing list of emerging viral diseases. This virus caused an outbreak of fatal respiratory disease in horses and humans. Genetic analyses show it to be only distantly related to the classic morbilliviruses rinderpest, measles, and canine distemper. When seen by electron microscopy, viruses had 10- and 18-nanometer surface projections that gave them a "double-fringed" appearance. The virus induced syncytia that developed in the endothelium of blood vessels, particularly the lungs.
MeSH terms
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Adult
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Amino Acid Sequence
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Animals
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Base Sequence
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Chlorocebus aethiops
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Disease Outbreaks / veterinary*
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Female
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Horse Diseases / epidemiology
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Horse Diseases / mortality
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Horse Diseases / virology*
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Horses
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Humans
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Kidney / virology
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Lung / virology
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Male
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Middle Aged
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Molecular Sequence Data
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Morbillivirus / genetics
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Morbillivirus / isolation & purification*
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Morbillivirus Infections / epidemiology
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Morbillivirus Infections / mortality
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Morbillivirus Infections / veterinary*
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Morbillivirus Infections / virology*
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Pregnancy
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Queensland / epidemiology
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Respiratory Tract Infections / veterinary
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Respiratory Tract Infections / virology
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Spleen / virology
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Vero Cells
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Virus Cultivation