Association between clozapine response and allelic variation in 5-HT2A receptor gene

Lancet. 1995 Jul 29;346(8970):281-2. doi: 10.1016/s0140-6736(95)92168-0.

Abstract

We report allelic association between a polymorphism (T102C) within the coding region of the 5-HT2A gene (HTR2A, 13q14-21) and response to clozapine in schizophrenic patients. Homozygosity for the C102 allele was more frequent (30/57, 53%) among patients who did not respond to clozapine than in those who responded (23/92, 25%). This finding is evidence that allelic variation of genes which encode neurotransmitter receptors can influence clinical response to antipsychotic drugs.

Publication types

  • Comparative Study

MeSH terms

  • Alleles*
  • Base Sequence
  • Clozapine / pharmacology*
  • Clozapine / therapeutic use
  • DNA Primers
  • Female
  • Genetic Variation / drug effects*
  • Genotype
  • Homozygote
  • Humans
  • Male
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Polymorphism, Genetic / drug effects
  • Receptor, Serotonin, 5-HT2A
  • Receptors, Serotonin / drug effects*
  • Receptors, Serotonin / genetics*
  • Schizophrenia / drug therapy
  • Schizophrenia / genetics

Substances

  • DNA Primers
  • Receptor, Serotonin, 5-HT2A
  • Receptors, Serotonin
  • Clozapine