Inhibitory role of the endothelium in the response of isolated coronary arteries to platelets

Science. 1983 Jul 15;221(4607):273-4. doi: 10.1126/science.6574604.

Abstract

Aggregating autologous platelets caused contraction of isolated rings of canine left circumflex arteries. The contractions were augmented after removal of the endothelium and were attenuated by serotonergic antagonists. During contraction caused by prostaglandin F2 alpha, aggregating platelets caused a transient increase in tension followed by a profound relaxation of arteries with endothelium, but caused only further contraction of arteries without endothelium. These observations demonstrate the importance of the vascular endothelium in opposing the constriction of coronary vessels caused by 5-hydroxytryptamine and other substances released from aggregating platelets.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Blood Platelets / physiology*
  • Coronary Vessels / physiology*
  • Dinoprost
  • Dogs
  • Endothelium / physiology
  • Muscle, Smooth, Vascular / physiology
  • Platelet Aggregation
  • Prostaglandins F / physiology
  • Serotonin / physiology
  • Vasoconstriction

Substances

  • Prostaglandins F
  • Serotonin
  • Dinoprost