Polypeptide transforming growth factors isolated from bovine sources and used for wound healing in vivo

Science. 1983 Mar 18;219(4590):1329-31. doi: 10.1126/science.6572416.

Abstract

Transforming growth factors, which are polypeptides that induce the transformed phenotype in nonneoplastic cells, have been isolated in bulk amounts from bovine salivary gland and kidney. In experiments in which wound healing chambers were implanted subcutaneously in the backs of rats, these bovine transforming growth factors accelerated the accumulation of total protein, collagen, and DNA in treated chambers. These studies thus show an effect of an isolated transforming growth factor in vivo.

MeSH terms

  • Animals
  • Cattle
  • Growth Substances / isolation & purification*
  • Growth Substances / pharmacology
  • Kidney / analysis
  • Peptides / pharmacology*
  • Salivary Glands / analysis
  • Transforming Growth Factors
  • Wound Healing / drug effects*

Substances

  • Growth Substances
  • Peptides
  • Transforming Growth Factors