Abstract
Cynomolgus macaques were fed autoclaved alfalfa seeds for up to 1 yr. There were no humoral signs of a syndrome resembling systemic lupus erythematosus. The data are in contrast to those previously reported in monkeys fed raw alfalfa seeds, in which a systemic lupus erythematosus-like syndrome was induced in a shorter interval. The autoclaved seeds retained antihypercholesterolaemic effects.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Anemia / etiology
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Animal Feed / toxicity
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Animals
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Autoimmune Diseases / etiology
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Canavanine / analysis
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Canavanine / toxicity
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Complement C3 / analysis
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Complement C4 / analysis
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Female
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Hot Temperature
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Hypercholesterolemia / prevention & control
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Immunoglobulin G / analysis
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Lupus Erythematosus, Systemic / etiology
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Macaca fascicularis
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Medicago sativa / analysis
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Medicago sativa / toxicity*
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Plants, Edible* / analysis
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Seeds / analysis
Substances
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Complement C3
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Complement C4
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Immunoglobulin G
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Canavanine