Abstract
A chinese patient with hemoglobin (Hb) H and Hb New York is described. Unlike classical Hb H disease, the additional beta New York chain defect resulted in a more marked alpha/beta-globin chain imbalance in this patient with only one alpha-gene, accounting for her severe anemia (3.4-6.8 g/dl) during the steady state.
MeSH terms
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Adult
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Anemia / genetics
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Anemia / therapy
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Blood Transfusion
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Chromosome Deletion
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DNA / analysis
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Erythrocyte Aging
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Female
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Globins / biosynthesis
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Globins / genetics*
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Hemoglobins, Abnormal / analysis*
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Humans
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Thalassemia / etiology*
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Thalassemia / genetics
Substances
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Hemoglobins, Abnormal
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Globins
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DNA
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hemoglobin New York