High dose ketoconazole in the treatment of cerebral aspergilloma

Clin Neurol Neurosurg. 1987;89(3):193-6. doi: 10.1016/s0303-8467(87)80054-9.

Abstract

A 32-year-old Chinese woman with bilateral occipital aspergilloma was treated successfully with high dose ketoconazole (1200 mg/day) for six months in conjunction with amphotericin B and 5-fluorocytosine. No unacceptable side effects occurred. The use of high dose ketoconazole could be considered in CNS aspergillosis unresponsive to conventional anti-fungal therapy.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Amphotericin B / therapeutic use
  • Aspergillosis / diagnostic imaging
  • Aspergillosis / drug therapy*
  • Brain Diseases / drug therapy*
  • Brain Diseases / microbiology
  • Drug Therapy, Combination
  • Female
  • Flucytosine / therapeutic use
  • Hong Kong
  • Humans
  • Ketoconazole / administration & dosage
  • Ketoconazole / therapeutic use*
  • Tomography, X-Ray Computed

Substances

  • Amphotericin B
  • Flucytosine
  • Ketoconazole