MiR-211 plays a dual role in cancer development: From tumor suppressor to tumor enhancer

Hanieh Shirvani; Jalaledin Ghanavi; Amin Aliabadi; Fatemehsadat Mousavinasab; Mehrdad Talebi; Jamal Majidpoor; Sajad Najafi; Seyyed Mohammad Miryounesi; Seyed Mohsen Aghaei Zarch

doi:10.1016/j.cellsig.2022.110504

MiR-211 plays a dual role in cancer development: From tumor suppressor to tumor enhancer

Cell Signal. 2023 Jan:101:110504. doi: 10.1016/j.cellsig.2022.110504. Epub 2022 Oct 26.

Authors

Hanieh Shirvani¹, Jalaledin Ghanavi², Amin Aliabadi³, Fatemehsadat Mousavinasab⁴, Mehrdad Talebi⁵, Jamal Majidpoor⁶, Sajad Najafi⁷, Seyyed Mohammad Miryounesi⁸, Seyed Mohsen Aghaei Zarch⁹

Affiliations

¹ Nanoscience Center, Department of Biological and Environmental Science, University of Jyväskylä, 40014 Jyväskylä, Finland.
² Mycobacteriology Research Centre, National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
³ Department of Pharmaceutics and Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁴ Department of Medical Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁵ Department of Medical Genetics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
⁶ Department of Anatomy, Faculty of Medicine, Infectious Disease Research Center, Gonabad University of Medical Sciences, Gonabad, Iran.
⁷ Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: sajadnajafi1990@yahoo.com.
⁸ Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: miryounesi@sbmu.ac.ir.
⁹ Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: mosenaghaei123@gmail.com.

PMID: 36309329
DOI: 10.1016/j.cellsig.2022.110504

Abstract

Cancer is a general term for more than 100 unique malignancies in different organs of the body. Each cancer type and subtype has its own unique genetic, epigenetic, and cellular factors accountable for malignant progression and metastasis. Small non-coding RNAs called miRNAs target mRNAs and play a vital part in the pathogenesis of human diseases, specifically cancer. Recent investigations provided knowledge of the deregulation of miR-211 in various cancer types and disclosed that miR-211 has an oncogenic or tumor-suppressive impact on tumourigenesis and cancer development. Moreover, recent discoveries which clarify the essential functions of miR-211 might provide proof for its prognosis, diagnostic and therapeutic impact on cancer. Thereby, this review will discuss recent findings regarding miR-211 expression level, target genes, and mechanisms in different cancers. In addition, the most recent results that propose miR-211 usefulness as a noninvasive biomarker and therapeutic factor for the diagnosis and treatment of cancer will be explained.

Keywords: Cancer; Diagnosis; Prognosis; Proto-oncogene; Tumor suppressor; miR-211.

Publication types

Review

MeSH terms

Carcinogenesis / genetics
Genes, Tumor Suppressor
Humans
MicroRNAs* / genetics
MicroRNAs* / metabolism
Neoplasms* / genetics
Oncogenes

Substances

MicroRNAs
MIRN211 microRNA, human