We analyzed the interaction between miR-25 and SNHG4 in papillary thyroid cancer (PTC). LncRNA SNHG4 was identified as an oncogene in osteosarcoma. We analyzed The Cancer Genome Atlas (TCGA) data and found that SNHG4 was downregulated in papillary thyroid cancer (PTC). Sixty patients with PTC were enrolled. SNHG4 expression in paired PTC tissues and adjacent normal tissues from the 60 PTC patients was analyzed by reverse transcription quantitative polymerase chain reaction. The proliferation of IHH-4 cells with SNHG4, miR-25 or FBXW7 overexpression was analyzed by cell proliferation assay. SNHG4 was downregulated in PTC tissues compared with the adjacent normal tissues of PTC patients. SNHG4 sponged with miR-25, while SNHG4 and miR-25 overexpression failed to alter each other. SNHG4 overexpression resulted in upregulated FBXW7, which is a targeted of miR-25. miR-25 overexpression increased PTC cell proliferation. Overexpression of SNHG4 and FBXW7 played an opposite role and abolished the effect of miR-25 overexpression. SNHG4 may interact with the miR-25/FBXW7 axis to suppress PTC cell proliferation.