Integrase Strand Transfer Inhibitors and Weight Gain in Children and Youth With Perinatal Human Immunodeficiency Virus in the DC Cohort

Wei Li A Koay; Sahera Dirajlal-Fargo; Matthew E Levy; Paige Kulie; Anne Monroe; Amanda D Castel; Natella Y Rakhmanina; DC Cohort Executive Committee

doi:10.1093/ofid/ofab308

Integrase Strand Transfer Inhibitors and Weight Gain in Children and Youth With Perinatal Human Immunodeficiency Virus in the DC Cohort

Open Forum Infect Dis. 2021 Jul 1;8(7):ofab308. doi: 10.1093/ofid/ofab308. eCollection 2021 Jul.

Authors

Wei Li A Koay^{1

2}, Sahera Dirajlal-Fargo^{3

4

5}, Matthew E Levy^{6

7}, Paige Kulie⁶, Anne Monroe⁶, Amanda D Castel⁶, Natella Y Rakhmanina^{1

2

8}; DC Cohort Executive Committee

Collaborators

Affiliations

¹ Department of Infectious Diseases, Children's National Hospital, Washington, District of Columbia, USA.
² School of Medicine and Health Sciences, George Washington University, Washington, District of Columbia, USA.
³ School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
⁴ University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
⁵ Pediatric Infectious Diseases, Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA.
⁶ Milken Institute School of Public Health, George Washington University, Washington, District of Columbia, USA.
⁷ Westat, Rockville, Maryland, USA.
⁸ Elizabeth Glaser Pediatric AIDS Foundation, Washington, District of Columbia, USA.

Abstract

We conducted a retrospective analysis of 38 children and youth with human immunodeficiency virus (aged 0-19 years) in the United States and report an increased rate of change of BMI-for-age z score after initiating integrase strand transfer inhibitors (+0.19 z score units/year [95% confidence interval, .01-.37]; P = .036) for a median follow-up of 527.5 days.

Keywords: HIV; adolescents; body mass index; integrase inhibitors; youth.

Abstract

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