The long and the small collide: LncRNAs and small heterodimer partner (SHP) in liver disease

Mol Cell Endocrinol. 2021 May 15:528:111262. doi: 10.1016/j.mce.2021.111262. Epub 2021 Mar 26.

Abstract

Long non-coding RNAs (lncRNAs) are a large and diverse class of RNA molecules that are transcribed but not translated into proteins, with a length of more than 200 nucleotides. LncRNAs are involved in gene expression and regulation. The abnormal expression of lncRNAs is associated with disease pathogenesis. Small heterodimer partner (SHP, NR0B2) is a unique orphan nuclear receptor that plays a pivotal role in many biological processes by acting as a transcriptional repressor. In this review, we present the critical roles of SHP and summarize recent findings demonstrating the regulation between lncRNAs and SHP in liver disease.

Keywords: Non-coding RNAs; Nuclear receptor; SHP; lncRNAs.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Gene Expression Regulation
  • Humans
  • Lipid Metabolism
  • Liver Diseases / genetics*
  • Liver Diseases / metabolism
  • RNA, Long Noncoding / genetics*
  • Receptors, Cytoplasmic and Nuclear / genetics*
  • Receptors, Cytoplasmic and Nuclear / metabolism

Substances

  • RNA, Long Noncoding
  • Receptors, Cytoplasmic and Nuclear
  • nuclear receptor subfamily 0, group B, member 2