A retrospective study of gallbladders submitted as surgical specimens over a period of fifteen years (1972-1986) was performed in the Department of Pathology, Queen Mary Hospital, Hong Kong. Seven thousand nine hundred and ten gallbladders were examined. A total of 253 more unusual and significant pathological lesions were recorded. The diagnoses made in these cases, in descending order of frequency, were primary carcinoma, metastatic carcinoma, adenoma, clonorchiasis and others. In 76 gallbladders clinically significant pathology was first discovered on pathological examination.